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Explore Clinical Trials & Research for Rare Disease Patients

Palistine, OH Train Derailing: Known Chemical Hazards as of 2_15_2023

Association of COVID-19 with short- and long-term risk of cardiovascular disease and mortality: a prospective cohort in UK Biobank - PubMed

Long-term mortality following SARS-CoV-2 infection: A national cohort study from Estonia - PubMed

COVID-19 Post-acute Sequelae Among Adults: 12 Month Mortality Risk - PubMed

High-dimensional characterization of post-acute sequelae of COVID-19 - Nature

WSJ: Are Vaccines Fueling New Covid Variants?

Review of the Cleveland Clinic Study: "Effectiveness of the Coronavirus Disease 2019 (COVID-19) Bivalent Vaccine"

Analysis of Florida Department of Health: Guidance on Childhood Vaccines

Analysis: Florida Department of Health's Vaccine Guidance

High vaccination coverage slows down genetic diversity of SARS-CoV-2 - PubMed

COVID-19 vaccines dampen genomic diversity of SARS-CoV-2: Unvaccinated patients exhibit more antigenic mutational variance

Fact Check-No evidence vaccination efforts are causing new COVID-19...

Long-Term Evolution of SARS-CoV-2 in an Immunocompromised Patient with Non-Hodgkin Lymphoma - PubMed

Persistent SARS-CoV-2 infection in immunocompromised patients facilitates rapid viral evolution: Retrospective cohort study and literature review

Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host - Nature Communications

XBB Covid-19 wave may peak in S’pore earlier than mid-November: Ong Ye Kung

Fact Check: Do Booster Shots Increase a Person’s Likelihood of Getting COVID?

Impaired function and delayed regeneration of dendritic cells in COVID-19

Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection - PubMed

Profound dysregulation of T cell homeostasis and function in patients with severe COVID-19 - PubMed

Dysregulated naive B cells and de novo autoreactivity in severe COVID-19 - Nature

Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

T-cell dysfunction as a potential contributing factor in post-COVID-19 mucormycosis - PubMed

T cell perturbations persist for at least 6 months following hospitalization for COVID-19

Alterations in T and B cell function persist in convalescent COVID-19 patients - PubMed

Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study - PubMed

Remodeling of T Cell Dynamics During Long COVID Is Dependent on Severity of SARS-CoV-2 Infection - PubMed

Neuro-COVID long-haulers exhibit broad dysfunction in T cell memory generation and responses to vaccination

Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease - PubMed

Severe Adaptive Immune Suppression May Be Why Patients With Severe COVID-19 Cannot Be Discharged From the ICU Even After Negative Viral Tests - PubMed

T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis - PubMed

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection - PubMed

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection - PubMed

Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection - PubMed

Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis - PubMed

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia - PubMed

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection - PubMed

Profound Treg perturbations correlate with COVID-19 severity - PubMed

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) - PubMed

A regulatory T cell signature distinguishes the immune landscape of COVID-19 patients from those with other respiratory infections - PubMed

Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19 - PubMed

Lessons Learned Comparing Immune System Alterations of Bacterial Sepsis and SARS-CoV-2 Sepsis - PubMed

Persistent Autoimmune Activation and Proinflammatory State in Post-Coronavirus Disease 2019 Syndrome - PubMed

Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long-COVID symptoms - PubMed

Persistent Symptoms in Adult Patients 1 Year After Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study - PubMed

The impact of COVID-19 outbreak on the incidence of acute invasive fungal rhinosinusitis - PubMed

COVID associated mucormycosis: A preliminary study from a dedicated COVID Hospital in Delhi - PubMed

Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review - PubMed

COVID-19 and autoimmune diseases - PubMed

New Onset of Autoimmune Diseases Following COVID-19 Diagnosis - PubMed

Air Cleaners, HVAC Filters, and Coronavirus (COVID-19) | US EPA

Real-world data show that filters clean COVID-causing virus from air

SARS-CoV-2 aerosol transmission in schools: the effectiveness of different interventions - PubMed

CDC Study: HEPA Filters Reduce COVID-19 Spread in Schools – Smart Air

Do HEPA Filters Really Catch Coronavirus Particles?

Removal of Airborne Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Other Microbial Bioaerosols by Air Filtration on Coronavirus Disease 2019 (COVID-19) Surge Units

Air filter significantly reduces presence of airborne SARS-CoV-2 in COVID-19 wards

Efficacy of Ventilation, HEPA Air Cleaners, Universal Masking, and Physical Distancing for Reducing Exposure to Simulated Exhaled Aerosols in a Meeting Room

Cleaner air: Protection from COVID-19

Ventilation Can Reduce COVID-19 Risk | Yale School Of Public Health

Are the Portable Air Cleaners (PAC) really effective to terminate airborne SARS-CoV-2?

Let's Clear The Air On COVID - The White House

Can HVAC systems help prevent transmission of COVID-19?

Mask wearing in community settings reduces SARS-CoV-2 transmission

Harvard Report: Face masks: An essential protective measure while traveling

Harvard Study: Assessment of Risks of SARS-CoV-2 Transmission During Air Travel and Non-Pharmaceutical Interventions to Reduce Risk

Yale: Largest study on masks and Covid-19 demonstrates their effectiveness in the real world

Randomized Controlled Trial: Impact of community masking on COVID-19: A cluster-randomized trial in Bangladesh

An evidence review of face masks against COVID-19

Face masks for COVID pass their largest test yet

Effectiveness of face masks in blocking the transmission of SARS-CoV-2: A preliminary evaluation of masks used by SARS-CoV-2-infected individuals

An evidence review of face masks against COVID-19

Efficacy of masks and face coverings in controlling outward aerosol particle emission from expiratory activities

Effectiveness of Mask Wearing to Control Community Spread of SARS-CoV-2

Face Mask Use in the Community for Reducing the Spread of COVID-19: A Systematic Review

Effectiveness of Face Mask or Respirator Use in Indoor Public Settings for Prevention of SARS-CoV-2 Infection — California, February–December 2021

UCSF: Still Confused About Masks? Here’s the Science Behind How Face Masks Prevent Coronavirus

Johns Hopkins: Coronavirus Face Masks FAQs

Mayo Clinic: How well do face masks protect against COVID-19?

Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections

Having SARS-CoV-2 once confers much greater immunity than a vaccine—but no infection parties, please

Summary of Oxford UK Survey: COVID vaccines protect against Delta, but their effectiveness wanes

UK Oxford Survey: Impact of Delta on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK

Mayo Clinic Led Study: Comparison of two highly-effective mRNA vaccines for COVID-19 during periods of Alpha and Delta variant prevalence

August 13th, 2021 CDC Vaccine Update

Science Opinion Piece: A grim warning from Israel: Vaccination blunts, but does not defeat Delta

Correlation of SARS-CoV-2 Breakthrough Infections to Time-from-vaccine; Preliminary Study

SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness

ZOE Project Press Release: Is COVID vaccine protection fading?

(Vetted) Expert reaction to press release from the ZOE app on vaccine effectiveness over time

Link to Israeli Health Ministry Report Slides

Link to analysis re: local vaccination rates in Israel & vaccine efficacy

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

Early News Reports: Is Delta Also More Severe in Kids?

CDC: COVID DATA TRACKER

WHO Coronavirus (COVID-19) Dashboard Back to top

American Academy of Pediatrics: COVID-19 Guidance for Safe Schools

CDC: Know What to Expect at Your Child’s K- 12 School or Early Care and Education Program

Science Magazine: Reducing transmission of SARS-CoV-2

American Association of Pediatrics Increases in pediatric hospitalization: Children and COVID-19: State-Level Data Report

American Academy of Pediatrics: Children and COVID-19: State-Level Data Report

CDC: Families and COVID-19

CDC: County by County Data Tracker for Local Transmission Rates

Journal of the American Medical Association: Effectiveness of Mask Wearing to Control Community Spread of SARS-CoV-2

Johns Hopkins School of Medicine: Interview with Pediatric infectious diseases specialist Matthew Thomas, M.D.

European Journal of Pediatrics: To mask or not to mask children to overcome COVID-19

PNAS: An evidence review of face masks against COVID-19

UCSF: Still Confused About Masks? Here’s the Science Behind How Face Masks Prevent Coronavirus

Nature Oct 2020: Face masks: what the data say

CDC: Health Department-Reported Cases of Multisystem Inflammatory Syndrome in Children (MIS-C) in the United States ​caused by COVID

Children are affected by long COVID: Long COVID and kids: scientists race to find answers

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents

Alpha Variant Data for Kids with Long COVID: Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2

Early News Report More Children are being hospitalized: Unclear if Delta Variant is worse for chlidren, but it spreads better.

Emerging Picture (520 COVID deaths in Children 8_13_2021): Hospitals In Southern U.S. Report Record Numbers Of Children Hospitalized Amid Delta Surge—Though Deaths Still Extremely Rare

New CDC Data: COVID-19 Vaccination Safe for Pregnant People

COVID-19 Vaccines While Pregnant or Breastfeeding

Ovarian follicular function is not altered by SARS-Cov-2 infection or BNT162b2 mRNA Covid-19 vaccination

BNT162b2 mRNA Covid-19 vaccine does not impair sperm parameters

Receipt of mRNA COVID-19 vaccines preconception and during pregnancy and risk of self-reported spontaneous abortions, CDC v-safe COVID-19 Vaccine Pregnancy Registry 2020-21

Pregnancy, Postpartum Care, and COVID-19 Vaccination in 2021

Addressing anti-syncytin antibody levels, and fertility and breastfeeding concerns, following BNT162B2 COVID-19 mRNA vaccination

Potential risks of SARS-CoV-2 infection on reproductive health

Coronavirus Disease 2019 (COVID-19) Vaccines and Pregnancy

Lack of effects on female fertility and prenatal and postnatal offspring development in rats with BNT162b2, a mRNA-based COVID-19 vaccine

Exaptation of Retroviral Syncytin for Development of Syncytialized Placenta, Its Limited Homology to the SARS-CoV-2 Spike Protein and Arguments against Disturbing Narrative in the Context of COVID-19 Vaccination

Ovarian follicular function is not altered by SARS-Cov-2 infection or BNT162b2 mRNA Covid-19 vaccination

Johns Hopkins: The COVID-19 Vaccine and Pregnancy: What You Need to Know

Are COVID-19 vaccines safe in pregnancy?

Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons

Possible impact of COVID-19 on fertility and assisted reproductive technologies

Review of Animal Models used for SarsCoV2 Research: Animal models for COVID-19

Animal Study: BNT162b vaccines protect rhesus macaques from SARS-CoV-2

Animal Study: Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Animal Study: Immunogenicity of a DNA vaccine candidate for COVID-19

Animal Study: ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

Animal Study: A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates

ANIMAL MODELS used for SarsCov2 Vaccine Development

REVIEW Article: Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology

Animal Study: Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity

Animal Study: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Animal Study: DNA vaccine protection against SARS-CoV-2 in rhesus macaques

Animal Study: Respiratory disease in rhesus macaques inoculated with SARS-CoV-2

Animal Study: SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

Potential reason why containment of SARS-COV-2 spread is so difficult: Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

How is Immunity Measured in Animal Vaccine Trials? Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models

Vaccine Development and Testing Overview: Learning from the past: development of safe and effective COVID-19 vaccines

Johns Hopkins COVID-19 State by State Case rates

CDC: SarsCoV2 Variant Information

Johns Hopkins COVID-19 Dashboard

NextStrain.org SarsCoV2 Global Mutations (GISAID Subsample)

GISAID: Map of tracked variant occurrence

SarsCoV2 Mutation Rate: Comparison of Clinical Features and Outcomes of Medically Attended COVID-19 and Influenza Patients in a Defined Population in the 2020 Respiratory Virus Season

ARTICLE CITED as GOF #1: "Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus"

ARTICLE CITED as GOF #2: "A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence"

Gain-of-Function Research: Ethical Analysis

White House Archives GOF Research: Doing Diligence to Assess the Risks and Benefits of Life Sciences Gain-of-Function Research

Free Textbook: The Science of Biology

Free Textbook: Kuby Immunology, 6th Edition

Free Textbook: Medical Microbiology, 4th Edition

Free Textbook: Introduction to Medical Immunology

June 25th Technical Brief: SARS-CoV-2 variants of concern and variants under investigation in England

Book Chapter "Dangerous Science: Science Policy and Risk Analysis for Scientists and Engineers" Case Study: H5N1 Influenza Research Debate

Pre-Print: AstraZeneca & Pfizer Vaccine Efficacy against Alpha & Delta Variants (title: Effectiveness of COVID-19 vaccines against the B.1.617.2 variant)

June 23rd Delta Variant: Delta variant triggers dangerous new phase in the pandemic

43,548 participant Clinical Trial Report Dec 2020: Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

Review: Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics

Registered SarsCoV2 Clinical Trials (therapeutics, supplements, vaccines)

CDC: Myocarditis and Pericarditis Following mRNA COVID-19 Vaccination

Official Statement American Heart Association: CDC investigating rare myocarditis in teens, young adults; COVID-19 vaccine still advised for all who are eligible

Webcast Link: CDC ACIP Meeting June 23-25th - Myocarditis Focus

ACIP: Advisory Committee on Immunization Practices

Moderna Vaccine: Minimal Amounts of Spike Protein Detected Post Vaccination

Prevalence of Clinical and Subclinical Myocarditis in Competitive Athletes With Recent SARS-CoV-2 Infection: Results From the Big Ten COVID-19 Cardiac Registry

Myopericarditis following smallpox vaccination among vaccinia-naive US military personnel

January 2021: Review on Up-to-Date Status of Candidate Vaccines for COVID-19 Disease

Known Distribution Patterns of DNA based Vaccines (pub. 2010)

DART Data Reported (here and elsewhere): Vaccines and Related Biological Products Advisory Committee December 17, 2020 Presentation - Emergency Use Authorization (EUA) Application for mRNA-1273