@cga_lab
How does neuronal trafficking underlie synapse loss during aging and AD?
@cga_lab Instagram
@cga_lab Instagram
@cga_lab X
@cga_lab X
Claudia Guimas Almeida profile at NOVA Research
Claudia Guimas Almeida profile at NOVA Research
Lab website
Lab website
PAPER: Burrinha et al., 2023: Deacidification of endolysosomes by neuronal aging drives synapse loss
PAPER: Burrinha et al., 2023: Deacidification of endolysosomes by neuronal aging drives synapse loss
PAPER: Perdigão et al., 2021: Bin1 increase intracellular abeta
PAPER: Perdigão et al., 2021: Bin1 increase intracellular abeta
Genetic studies have identified BIN1 as the second most important risk locus associated with late-onset Alzheimer's disease (LOAD). However, it is unclear how mutation of this locus mechanistically promotes Alzheimer’s disease (AD) pathology. Here we show the consequences of two coding variants in BIN1 (rs754834233 and rs138047593), both in terms of intracellular beta-amyloid (iAbeta) accumulation and early endosome enlargement, two interrelated early cytopathological AD phenotypes, supporting their association with LOAD risk.
PAPER Burrinha et al., 2021: Upregulation of APP endocytosis by neuronal aging
PAPER Burrinha et al., 2021: Upregulation of APP endocytosis by neuronal aging
Review: Aging impact on amyloid precursor protein neuronal trafficking
Review: Aging impact on amyloid precursor protein neuronal trafficking
Burrinha et al., 2023 - Cover Traffic
Burrinha et al., 2023 - Cover Traffic
NOVA | NIMS
NOVA | NIMS
Dr. Cláudia Almeida — Stories of WiN
Dr. Cláudia Almeida — Stories of WiN
Dr. Cláudia Almeida studies how neuronal trafficking dysfunction underlies synapse loss during aging and Alzheimer's disease.
Artigo na revista Público
Artigo na revista Público
Burrinha et al., 2021: Cover Journal of Cell Science
Burrinha et al., 2021: Cover Journal of Cell Science
Research highlight -Journal of Cell Science
Research highlight -Journal of Cell Science
Tatiana Burrinha: First Person interview with Journal of Cell Science
Tatiana Burrinha: First Person interview with Journal of Cell Science
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