Juan C. Landoni, PhD
Mitochondria | Translational Metabolism | Quantitative Imaging 🔬 Landoni Lab, University of Lausanne 🇨🇭
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Landoni Lab website
Landoni Lab website
Research group at UNIL specializing in mitochondria, metabolism, ageing, and advanced microscopy.
Research | Highlighted
Pearling drives mitochondrial DNA nucleoid distribution
Pearling drives mitochondrial DNA nucleoid distribution
The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regular positioning. In this work, we found that ...
Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network | Annual Reviews
Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network | Annual Reviews
Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network | Annual Reviews
Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation - Nature Communications
Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation - Nature Communications
IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder - European Journal of Human Genetics
IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder - European Journal of Human Genetics
Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias - Nature Metabolism
Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias - Nature Metabolism
Increased mitochondrial DNA (mtDNA) replication frequency is shown to lead to defects in maintenance of the nuclear genome due to reallocation of nucleotides to mitochondria, challenging the proposed direct role of mtDNA mutations as drivers of cellular and organismal ageing in mammalian progerias.
A complex genomic locus drives mtDNA replicase POLG expression to its disease‐related nervous system regions | EMBO Molecular Medicine
A complex genomic locus drives mtDNA replicase POLG expression to its disease‐related nervous system regions | EMBO Molecular Medicine
DNA polymerase gamma (POLG), the mtDNA replicase, is a common cause of mitochondrial neurodegeneration. Why POLG defects especially cause central nervous s
Science Communication
Mitochondrial Rap
Mitochondrial Rap
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EPFL Swiss Federal Institute of Technology in Lausanne - Cited by 294 - Mitochondria - Metabolism - Mitochondrial Disease - Aging - Microscopy
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