@SevenichLab
Tackling Brain Metastasis since 2015
Sevenich Lab
Prof. Dr. Lisa Sevenich | Universitätsklinikum Tübingen
Prof. Dr. Lisa Sevenich | Universitätsklinikum Tübingen
Sevenich Lab: Hertie-Institut für klinische Hirnforschung
Sevenich Lab: Hertie-Institut für klinische Hirnforschung
Dr. Lisa Sevenich - Georg-Speyer-Haus
Dr. Lisa Sevenich - Georg-Speyer-Haus
Sevenich Lab on twitter (X)
Sevenich Lab on twitter (X)
Sevenich Lab on ResearchGate
Sevenich Lab on ResearchGate
Principal Investigator: Lisa Sevenich | http://www.georg-speyer-haus.de/forschung/forschungsgruppen/sevenich/forschung.html https://twitter.com/LabSevenich https://linktr.ee/sevenichlab | ResearchGate, the professional network for scientists.
Recent Publications
Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis - Nature Cancer
Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis - Nature Cancer
Klemm et al. show that resistance to CSF1R inhibition in breast cancer brain metastasis is driven by compensatory activation of the CSF2Rb–STAT5 axis in macrophages, which can be alleviated by combined targeting of CSF1R and STAT5.
Deep sequencing reveals heterogeneity of brain metastasis-associated macrophages and microglia and uncovers their cell type-specific functions within the tumor microenvironment
Deep sequencing reveals heterogeneity of brain metastasis-associated macrophages and microglia and uncovers their cell type-specific functions within the tumor microenvironment
Cellular and Molecular Changes of Brain Metastases-Associated Myeloid Cells during Disease Progression and Therapeutic Response
Cellular and Molecular Changes of Brain Metastases-Associated Myeloid Cells during Disease Progression and Therapeutic Response
The immune suppressive microenvironment affects efficacy of radio-immunotherapy in brain metastasis
The immune suppressive microenvironment affects efficacy of radio-immunotherapy in brain metastasis
The tumor microenvironment in brain metastases is characterized by high myeloid cell content associated with immune suppressive and cancer‐permissive
Evaluating Magnetic Resonance Spectroscopy as a Tool for Monitoring Therapeutic Response of Whole Brain Radiotherapy in a Mouse Model for Breast-to-Brain Metastasis
Evaluating Magnetic Resonance Spectroscopy as a Tool for Monitoring Therapeutic Response of Whole Brain Radiotherapy in a Mouse Model for Breast-to-Brain Metastasis
Brain metastases are the most common intracranial tumor in adults and are associated with poor patient prognosis and median survival of only a few months. Tr...
Reviews & Previews
Take my breath away: TAM-ing anti-cancer immunity in hypoxic niches
Take my breath away: TAM-ing anti-cancer immunity in hypoxic niches
Decoding Single Cell Morphology in Osteotropic Breast Cancer Cells for Dissecting Their Migratory, Molecular and Biophysical Heterogeneity
Decoding Single Cell Morphology in Osteotropic Breast Cancer Cells for Dissecting Their Migratory, Molecular and Biophysical Heterogeneity
The Brain Pre-Metastatic Niche: Biological and Technical Advancements
The Brain Pre-Metastatic Niche: Biological and Technical Advancements
TAMs in Brain Metastasis: Molecular Signatures in Mouse and Man
TAMs in Brain Metastasis: Molecular Signatures in Mouse and Man
Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis
Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis
Activation of Microglia and Macrophages in Neurodegenerative Diseases
Activation of Microglia and Macrophages in Neurodegenerative Diseases
Analyzing the Role of Proteases in Breast Cancer Progression and Metastasis Using Primary Cells from Transgenic Oncomice
Analyzing the Role of Proteases in Breast Cancer Progression and Metastasis Using Primary Cells from Transgenic Oncomice
Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer
Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer
Inflammation is a hallmark of different central nervous system (CNS) pathologies. It has been linked to neurodegenerative disorders as well as primary and me...
Turning “Cold” Into “Hot” Tumors—Opportunities and Challenges for Radio-Immunotherapy Against Primary and Metastatic Brain Cancers
Turning “Cold” Into “Hot” Tumors—Opportunities and Challenges for Radio-Immunotherapy Against Primary and Metastatic Brain Cancers
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