@Melanie_Matheu_PhD

Melanie_Matheu_PhD has been a member of Linktree for 5 years and joined in June 2021. Resources Melanie_Matheu_PhD has populated their site with include: • LIL_Science Substack • Instagram • www.youtube.com • Threads • PODCAST WEBSITE • Newborn and Early Infant Outcomes Following Maternal COVID-19 Vaccination During Pregnancy • Evaluation of Acute Adverse Events after Covid-19 Vaccination during Pregnancy • Neonatal Outcomes After COVID-19 Vaccination in Pregnancy • Postacute Sequelae of SARS-CoV-2 in Children • Find COVID‑19 vaccine locations near you • No-Cost COVID-19 Testing​ • COVID-19 Test to Treat Locator - Where to find Paxlovid • Association of COVID-19 with short- and long-term risk of cardiovascular disease and mortality: a prospective cohort in UK Biobank - PubMed • Long-term mortality following SARS-CoV-2 infection: A national cohort study from Estonia - PubMed • COVID-19 Post-acute Sequelae Among Adults: 12 Month Mortality Risk - PubMed • High-dimensional characterization of post-acute sequelae of COVID-19 - Naturem, • How deadly is long Covid? Here's what a new CDC study found. • Exhaustion and over-activation of immune cells in COVID-19: Challenges and therapeutic opportunities • T cell response to SARS-CoV-2 infection in humans: A systematic review • Risk of autoimmune diseases in patients with COVID-19: A retrospective cohort study • B lymphocytes in COVID-19: a tale of harmony and discordance - PubMed • Mucormycosis: “The Black Fungus” trampling post-COVID-19 patients • The detectable anti-interferon-γ autoantibodies in COVID-19 patients may be associated with disease severity - Virology Journal • Distinguishing features of long COVID identified through immune profiling • Activation or exhaustion of CD8+ T cells in patients with COVID-19 - Cellular & Molecular Immunology • A comprehensive review about immune responses and exhaustion during coronavirus disease (COVID-19) - Cell Communication and Signaling • Surge of mucormycosis during the COVID-19 pandemic • Remodeling of T Cell Dynamics During Long COVID Is Dependent on Severity of SARS-CoV-2 Infection • Severe COVID-19 may lead to long-term innate immune system changes • Impaired function and delayed regeneration of dendritic cells in COVID-19 • Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19 - PubMed • Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection - PubMed • Profound dysregulation of T cell homeostasis and function in patients with severe COVID-19 - PubMed • Dysregulated naive B cells and de novo autoreactivity in severe COVID-19 - Nature • Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses • T-cell dysfunction as a potential contributing factor in post-COVID-19 mucormycosis - PubMed • T cell perturbations persist for at least 6 months following hospitalization for COVID-19 • Alterations in T and B cell function persist in convalescent COVID-19 patients - PubMed • Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study - PubMed • Lasting alterations in monocyte and dendritic cell subsets in individuals after 2 hospitalization for COVID-19 • Remodeling of T Cell Dynamics During Long COVID Is Dependent on Severity of SARS-CoV-2 Infection - PubMed • Neuro-COVID long-haulers exhibit broad dysfunction in T cell memory generation and responses to vaccination • Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease - PubMed • Severe Adaptive Immune Suppression May Be Why Patients With Severe COVID-19 Cannot Be Discharged From the ICU Even After Negative Viral Tests - PubMed • T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis - PubMed • Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection - PubMed • Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection - PubMed • Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection - PubMed • Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis - PubMed • Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia - PubMed • Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection - PubMed • Profound Treg perturbations correlate with COVID-19 severity - PubMed • A scoping review of regulatory T cell dynamics in convalescent COVID-19 patients – Implications for Long COVID? • Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) - PubMed • A regulatory T cell signature distinguishes the immune landscape of COVID-19 patients from those with other respiratory infections - PubMed • Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19 - PubMed • Lessons Learned Comparing Immune System Alterations of Bacterial Sepsis and SARS-CoV-2 Sepsis - PubMed • Persistent Autoimmune Activation and Proinflammatory State in Post-Coronavirus Disease 2019 Syndrome - PubMed • Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long-COVID symptoms - PubMed • Persistent Symptoms in Adult Patients 1 Year After Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study - PubMed • The impact of COVID-19 outbreak on the incidence of acute invasive fungal rhinosinusitis - PubMed • COVID associated mucormycosis: A preliminary study from a dedicated COVID Hospital in Delhi - PubMed • Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review - PubMed • COVID-19 and autoimmune diseases - PubMed • New Onset of Autoimmune Diseases Following COVID-19 Diagnosis - PubMed • Air Cleaners, HVAC Filters, and Coronavirus (COVID-19) | US EPA • Real-world data show that filters clean COVID-causing virus from air • SARS-CoV-2 aerosol transmission in schools: the effectiveness of different interventions - PubMed • CDC Study: HEPA Filters Reduce COVID-19 Spread in Schools – Smart Air • Do HEPA Filters Really Catch Coronavirus Particles? • Removal of Airborne Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Other Microbial Bioaerosols by Air Filtration on Coronavirus Disease 2019 (COVID-19) Surge Units • Air filter significantly reduces presence of airborne SARS-CoV-2 in COVID-19 wards • Use of Portable Air Cleaners and Transmission of COVID-19 • Efficacy of Ventilation, HEPA Air Cleaners, Universal Masking, and Physical Distancing for Reducing Exposure to Simulated Exhaled Aerosols in a Meeting Room • Portable HEPA Purifiers to Eliminate Airborne SARS-CoV-2: A Systematic Review • Cleaner air: Protection from COVID-19 • Ventilation Can Reduce COVID-19 Risk | Yale School Of Public Health • Are the Portable Air Cleaners (PAC) really effective to terminate airborne SARS-CoV-2? • Improving Ventilation in Schools, Colleges, and Universities to Prevent COVID-19 | U.S. Department of Education • Let's Clear The Air On COVID - The White House • Can HVAC systems help prevent transmission of COVID-19? • Testing mobile air purifiers in a school classroom: Reducing the airborne transmission risk for SARS-CoV-2 • Lifting Universal Masking in Schools — Covid-19 Incidence among Students and Staff • Mask wearing in community settings reduces SARS-CoV-2 transmission • Harvard Report: Face masks: An essential protective measure while traveling • Harvard Study: Assessment of Risks of SARS-CoV-2 Transmission During Air Travel and Non-Pharmaceutical Interventions to Reduce Risk • Yale: Largest study on masks and Covid-19 demonstrates their effectiveness in the real world • Randomized Controlled Trial: Impact of community masking on COVID-19: A cluster-randomized trial in Bangladesh • An evidence review of face masks against COVID-19 • Face masks for COVID pass their largest test yet • Effectiveness of face masks in blocking the transmission of SARS-CoV-2: A preliminary evaluation of masks used by SARS-CoV-2-infected individuals • Efficacy of masks and face coverings in controlling outward aerosol particle emission from expiratory activities • Effectiveness of Mask Wearing to Control Community Spread of SARS-CoV-2 • Face Mask Use in the Community for Reducing the Spread of COVID-19: A Systematic Review • Effectiveness of Face Mask or Respirator Use in Indoor Public Settings for Prevention of SARS-CoV-2 Infection — California, February–December 2021 • UCSF: Still Confused About Masks? Here’s the Science Behind How Face Masks Prevent Coronavirus • Johns Hopkins: Coronavirus Face Masks FAQs • Mayo Clinic: How well do face masks protect against COVID-19? • Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections • Having SARS-CoV-2 once confers much greater immunity than a vaccine—but no infection parties, please • Summary of Oxford UK Survey: COVID vaccines protect against Delta, but their effectiveness wanes • UK Oxford Survey: Impact of Delta on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK • Mayo Clinic Led Study: Comparison of two highly-effective mRNA vaccines for COVID-19 during periods of Alpha and Delta variant prevalence • August 13th, 2021 CDC Vaccine Update • Science Opinion Piece: A grim warning from Israel: Vaccination blunts, but does not defeat Delta • Correlation of SARS-CoV-2 Breakthrough Infections to Time-from-vaccine; Preliminary Study • SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness • ZOE Project Press Release: Is COVID vaccine protection fading? • (Vetted) Expert reaction to press release from the ZOE app on vaccine effectiveness over time • Link to Israeli Health Ministry Report Slides • Link to analysis re: local vaccination rates in Israel & vaccine efficacy • Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection • How the Delta variant achieves its ultrafast spread • SARS-CoV-2 viral load is associated with increased disease severity and mortality • Health Department-Reported Cases of Multisystem Inflammatory Syndrome in Children (MIS-C) in the United States ​ • Early News Reports: Is Delta Also More Severe in Kids? • Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome • Epidemiological and clinical features of pediatric COVID-19 • Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents • CDC: About Multisystem Inflammatory Syndrome (MIS) • COVID vaccines protect against Delta, but their effectiveness wanes • Intraseason Waning of Influenza Vaccine Effectiveness • Decline in Seasonal Influenza Vaccine Effectiveness With Vaccination Program Maturation: A Systematic Review and Meta-analysis • Efficacy of Influenza Vaccine in Nursing Homes Reduction in Illness and Complications During an Influenza A (H3N2) Epidemic • Effectiveness of Influenza Vaccine for Preventing Laboratory-Confirmed Influenza Hospitalizations in Adults, 2011–2012 Influenza Season • CDC Report on Delta Variant from July 29th, 2021 • Influenza Vaccine Given to Pregnant Women Reduces Hospitalization Due to Influenza in Their Infants • Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism • Patterns of Influenza Vaccination and Vaccine Effectiveness Among Young US Children Who Receive Outpatient Care for Acute Respiratory Tract Illness • CDC: COVID DATA TRACKER • WHO Coronavirus (COVID-19) Dashboard Back to top • American Academy of Pediatrics: COVID-19 Guidance for Safe Schools • CDC: Know What to Expect at Your Child’s K- 12 School or Early Care and Education Program • Science Magazine: Reducing transmission of SARS-CoV-2 • American Association of Pediatrics Increases in pediatric hospitalization: Children and COVID-19: State-Level Data Report • American Academy of Pediatrics: Children and COVID-19: State-Level Data Report • CDC: Families and COVID-19 • CDC: County by County Data Tracker for Local Transmission Rates • Journal of the American Medical Association: Effectiveness of Mask Wearing to Control Community Spread of SARS-CoV-2 • Johns Hopkins School of Medicine: Interview with Pediatric infectious diseases specialist Matthew Thomas, M.D. • European Journal of Pediatrics: To mask or not to mask children to overcome COVID-19 • PNAS: An evidence review of face masks against COVID-19 • Nature Oct 2020: Face masks: what the data say • CDC: Health Department-Reported Cases of Multisystem Inflammatory Syndrome in Children (MIS-C) in the United States ​caused by COVID • Children are affected by long COVID: Long COVID and kids: scientists race to find answers • Children With Long COVID • Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents • Alpha Variant Data for Kids with Long COVID: Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2 • Early News Report More Children are being hospitalized: Unclear if Delta Variant is worse for chlidren, but it spreads better. • Emerging Picture (520 COVID deaths in Children 8_13_2021): Hospitals In Southern U.S. Report Record Numbers Of Children Hospitalized Amid Delta Surge—Though Deaths Still Extremely Rare • New CDC Data: COVID-19 Vaccination Safe for Pregnant People • COVID-19 Vaccines While Pregnant or Breastfeeding • Ovarian follicular function is not altered by SARS-Cov-2 infection or BNT162b2 mRNA Covid-19 vaccination • BNT162b2 mRNA Covid-19 vaccine does not impair sperm parameters • Receipt of mRNA COVID-19 vaccines preconception and during pregnancy and risk of self-reported spontaneous abortions, CDC v-safe COVID-19 Vaccine Pregnancy Registry 2020-21 • Pregnancy, Postpartum Care, and COVID-19 Vaccination in 2021 • Addressing anti-syncytin antibody levels, and fertility and breastfeeding concerns, following BNT162B2 COVID-19 mRNA vaccination • Potential risks of SARS-CoV-2 infection on reproductive health • Coronavirus Disease 2019 (COVID-19) Vaccines and Pregnancy • Lack of effects on female fertility and prenatal and postnatal offspring development in rats with BNT162b2, a mRNA-based COVID-19 vaccine • Exaptation of Retroviral Syncytin for Development of Syncytialized Placenta, Its Limited Homology to the SARS-CoV-2 Spike Protein and Arguments against Disturbing Narrative in the Context of COVID-19 Vaccination • Johns Hopkins: The COVID-19 Vaccine and Pregnancy: What You Need to Know • Are COVID-19 vaccines safe in pregnancy? • Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons • Possible impact of COVID-19 on fertility and assisted reproductive technologies • Review of Animal Models used for SarsCoV2 Research: Animal models for COVID-19 • Animal Study: BNT162b vaccines protect rhesus macaques from SARS-CoV-2 • Animal Study: Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates • Animal Study: Immunogenicity of a DNA vaccine candidate for COVID-19 • Animal Study: ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques • Animal Study: A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates • ANIMAL MODELS used for SarsCov2 Vaccine Development • REVIEW Article: Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology • Animal Study: Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity • Animal Study: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques • Animal Study: DNA vaccine protection against SARS-CoV-2 in rhesus macaques • Animal Study: Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 • Animal Study: SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness • Potential reason why containment of SARS-COV-2 spread is so difficult: Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model • How is Immunity Measured in Animal Vaccine Trials? Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models • Vaccine Development and Testing Overview: Learning from the past: development of safe and effective COVID-19 vaccines • Johns Hopkins COVID-19 State by State Case rates • CDC: SarsCoV2 Variant Information • Johns Hopkins COVID-19 Dashboard • NextStrain.org SarsCoV2 Global Mutations (GISAID Subsample) • GISAID: Map of tracked variant occurrence • SarsCoV2 Mutation Rate: Comparison of Clinical Features and Outcomes of Medically Attended COVID-19 and Influenza Patients in a Defined Population in the 2020 Respiratory Virus Season • ARTICLE CITED as GOF #1: "Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus" • ARTICLE CITED as GOF #2: "A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence" • Gain-of-Function Research: Ethical Analysis • White House Archives GOF Research: Doing Diligence to Assess the Risks and Benefits of Life Sciences Gain-of-Function Research • Free Textbook: The Science of Biology • Free Textbook: Kuby Immunology, 6th Edition • Free Textbook: Medical Microbiology, 4th Edition • Free Textbook: Introduction to Medical Immunology • June 25th Technical Brief: SARS-CoV-2 variants of concern and variants under investigation in England • Book Chapter "Dangerous Science: Science Policy and Risk Analysis for Scientists and Engineers" Case Study: H5N1 Influenza Research Debate • Pre-Print: AstraZeneca & Pfizer Vaccine Efficacy against Alpha & Delta Variants (title: Effectiveness of COVID-19 vaccines against the B.1.617.2 variant) • June 23rd Delta Variant: Delta variant triggers dangerous new phase in the pandemic • 43,548 participant Clinical Trial Report Dec 2020: Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine • Review: Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics • Registered SarsCoV2 Clinical Trials (therapeutics, supplements, vaccines) • CDC: Myocarditis and Pericarditis Following mRNA COVID-19 Vaccination • Official Statement American Heart Association: CDC investigating rare myocarditis in teens, young adults; COVID-19 vaccine still advised for all who are eligible • Webcast Link: CDC ACIP Meeting June 23-25th - Myocarditis Focus • ACIP: Advisory Committee on Immunization Practices • Moderna Vaccine: Minimal Amounts of Spike Protein Detected Post Vaccination • Prevalence of Clinical and Subclinical Myocarditis in Competitive Athletes With Recent SARS-CoV-2 Infection: Results From the Big Ten COVID-19 Cardiac Registry • Myopericarditis following smallpox vaccination among vaccinia-naive US military personnel • January 2021: Review on Up-to-Date Status of Candidate Vaccines for COVID-19 Disease • Known Distribution Patterns of DNA based Vaccines (pub. 2010) • DART Data Reported (here and elsewhere): Vaccines and Related Biological Products Advisory Committee December 17, 2020 Presentation - Emergency Use Authorization (EUA) Application for mRNA-1273